INHIBITEURS À LARGE SPECTRE DE FILOVIRUS

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专利权人:

Albert Einstein College of Medicine, Inc.;The Government of the United States, as represented by the Secretary of the Army;Microbiotix, Inc.

发明人:

BOWLIN, Terry, L.,MOIR, Donald, T.,CHANDRAN, Kartik,DYE, John M, Jr.,WILLIAMS, John, D.,ARON, Zachary, D.,BARBOR, Katherine, S.,LIVELY, Kelly, N.,NASH, Peter, J.,MILLS, Debra, M.,BASU, Arnab

申请号：

EP17878089

公开号：

EP3548034A4

申请日:

2017.12.05

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

The present invention is related to the development of therapeutics and prophylactics for the treatment and/or prevention of filovirus infection in humans and other mammals. A new class of small molecules is disclosed that inhibits the interaction of naturally processed (i.e., proteolytically cleaved) filovirus glycoprotein (GPCL) with its host receptor Niemann-Pick C1 (NPC1) protein and thus block infection of host cells by filoviruses. Also disclosed are methods of using the small molecule inhibitors in the treatment/prevention of filovirus infection.

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