BEJR Kennet V. (US),БЭЙР Кеннет В. (US),BAKMELTER Aleksandr Dzh. (US),БАКМЕЛЬТЕР Александр Дж. (US),KHAN Binsun (US),ХАН Бинсун (US),LIN TSzyan (US),ЛИНЬ Цзянь (US),REJNOLDS Dominik Dzh. (US),РЕЙНОЛЬД,BEJR Kennet V.,БЭЙР Кеннет В.,BAKMELTER Aleksandr Dzh.,БАКМЕЛЬТЕР Александр Дж.,KHAN Binsun,ХАН Бинсун,LIN TSzyan,ЛИНЬ Цзянь,REJNOLDS Dominik Dzh.,РЕЙНОЛЬДС Доминик Дж.,SMIT CHejz K.,СМИТ Чейз К.,VAN
申请号：
RU2013114848/04
公开号：
RU0002593759C2
申请日:
2011.09.02
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula II:,where Ar1 represents a 6-10-member heteroaryl, where heteroaryl relates to a monocyclic or bicyclic heteroaryl containing 1, 2 or 3 heteroatoms selected from N, S or O, provided that two adjacent heteroatoms in ring can not both represent S or both represent O； Ar2 is phenyl； R1 is phenyl, 5-12-member heterocycloalkyl or 5-12-member heteroaryl (i), where each of said phenyl, heterocycloalkyl and heteroaryl is either unsubstituted or optionally independently substituted with 1, 2, 3, 4 or 5 substitutes, which can be identical or different and are independently selected from a group consisting of: halogen, cyano, alkyl, halogenalkyl, alkoxy, halogenalkoxy, -NRaRb, -CONaRb, -S(O)2-alkyl,-S(O)2N(alkyl)2, -(CH2)qaryl, -(CH2)qheteroaryl and -(CH2)qheterocycloalkyl, (ii) where each of said phenyl can further be unsubstituted or substituted with one or more substitutes, such as halogen, cyano, alkyl or alkoxy, or can be optionally condensed with independently selected arylheteroaryl or heterocycloalkyl； Ra and Rb independently represent H, alkyl,-S(O)2alkyl and cycloalkyl, or Ra and Rbcan form a 5- or 6-member heterocycloalkyl group together with a nitrogen atom to which they are bonded, where said heterocycloalkyl group may contain one or more additional heteroatoms selected from N, S or O； (iii) said 5-12-member heterocycloalkyl contains 1, 2 or 3 heteroatoms selected from N, S or O； (iv) said 5-12-member heteroaryl contains 1, 2 or 3 heteroatoms selected from N, S or O； R2 and R3 represent H, m, n, p and q independently are equal to 0, 1 or 2； and their pharmaceutically acceptable salts.EFFECT: compounds can be used to inhibit NAMPT.29 cl, 3 tbl, 5 exИзобретение относится к соединению формулы II:где Ar1 представляет собой 6-10-членный гетероарил, где гетероарил относится к моноциклическому или бициклическому гетероарилу, содержащему 1, 2 или 3 гетероатома, выбранных из N, S или О, при условии, ч
