IMMUNOMODULATOR COMPOUNDS AND METHODS OF USE

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专利权人:

INCYTE CORPORATION

发明人:

LIU, Phillip C.,VOLGINA, Alla,WYNN, Richard,ZOLOTARJOVA, Nina,WU, Liangxing,XIAO, Kaijiong,MEI, Song,LU, Liang,ZHU, Wenyu,YE, Yingda,QIAN, Ding-Quan,YAO, Wenqing,WANG, Haisheng

申请号：

PH12019501448

公开号：

PH12019501448A1

申请日:

2019.06.21

申请国别(地区):

PH

年份:

2020

代理人:

摘要：

Compositions and methods for inducing PD-L1 internalization are disclosed. The methods include reducing the amount of cell surface PD-L1 by contacting a cell expressing PD-L1 with a compound that binds to cell surface PD-L1 and induces PD-L1 internalization. Compounds that induce PD-L1 internalization can be used to enhance, stimulate and/or increase an immune response and treat a PD-1 -related disease or condition.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/