Fondazione Istituto Italiano di Tecnologia;Universita degli Studi di Parma;Universita degli Studi di Urbino "Carlo Bo";The Regents of the University of California
发明人:
Piomelli, Daniele,Moreno-Sanz, Guillermo,Bandiera, Tiziano,Mor, Marco,Tarzia, Giorgio
申请号：
AU2012299060
公开号：
AU2012299060A1
申请日:
2012.08.17
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention provides methods of making and using peripherally restricted inhibitors of fatty acid amide hydrolase (FAAH). The present invention provides compounds and compositions that suppress FAAH activity and increases anandamide levels outside the central nervous system (CNS). The present invention also sets forth methods for inhibiting FAAH as well as methods for treating conditions such as, but not limited to, pain, inflammation, immune disorders, dermatitis, mucositis, the over reactivity of peripheral sensory neurons, neurodermatitis, and an overactive bladder. Accordingly, the invention also provides compounds, methods, and pharmaceutical compositions for treating conditions in which the selective inhibition of peripheral FAAH (as opposed to CNS FAAH) would be of benefit.
