RAILLARD, Stephen P;XENOPORT;XENOPORT, INC.; INC.;MANTHATI, Suresh K;JOSHI, Sudhir
发明人:
RAILLARD, Stephen P,MANTHATI, Suresh K,JOSHI, Sudhir
申请号：
USUS2012/050379
公开号：
WO2013/023155A1
申请日:
2012.08.10
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.L'invention concerne un acide (3R)-4-{[(1S)-2-méthyl-1-(2-méthylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophényl)butanoïque anhydrate cristallin et un acide (3R)-4-{[(1S)-2-méthyl-1-(2-méthylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophényl)butanoïque hémihydrate cristallin, des compositions pharmaceutiques comprenant ces composés, des procédés de fabrication et des procédés d'utilisation de ces composés.
