PROBLEM TO BE SOLVED: To provide a chemical sprayer having an enhanced operability of an operating tool. SOLUTION: A drug sprayer has a drug tank for storing a drug, a drug spraying portion for spraying the drug stored in the drug tank, an allowable state for allowing differential between the left and right wheels, and a difference between the left and right wheels. A differential device configured to switch between a prohibited state that prohibits movement, a pedal 71 that accepts an operation to switch between the allowable state and the prohibited state of the differential device, and a support column 221 that supports the pedal 71. A left main frame and a right main frame 302 extending along the front-rear direction of the machine body, and a reinforcing frame 304 provided across the left main frame and the right main frame 302 are provided. The reinforcing frame 304 is provided with a guide portion 304a for guiding the movement of the support column. [Selection diagram] FIG. 9【課題】操作具の操作感を高めた薬剤散布機を提供する。【解決手段】薬剤散布機は、薬剤を貯留する薬剤タンクと、薬剤タンクに貯留された薬剤を散布する薬剤散布部と、左右の車輪の差動を許容する許容状態と、左右の車輪の差動を禁止する禁止状態と、の間で状態を切り替え可能に構成された差動装置と、差動装置の許容状態と禁止状態とを切り替える操作を受け付けるペダル71と、ペダル71を支持する支柱221と、機体前後方向に沿って伸びる左主フレーム及び右主フレーム302と、左主フレームと右主フレーム302とに渡って設けられる補強フレーム304と、を備える。補強フレーム304に、支柱の移動を案内する案内部304aが設けられている。【選択図】図9