Rodolfo R. Llinas,Herman Moreno,Mutsuyuki Sugimori
申请号：
US13756743
公开号：
US20140220036A1
申请日:
2013.02.01
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides methods of inhibiting a tau protein such as h-tau42 or a biologically active fragment, derivative or analog thereof, methods of treating a disease caused by a tau protein such as h-tau42, and methods to identify agents that may inhibit a tau protein such as h-tau42. The methods for identifying an agent effective to inhibit a tau protein may feature administering an agent and observing either i) a reduction in biological activity of the tau protein or a biologically active fragment, derivative or analog thereof or ii) a reduction in phosphorylation of the tau protein or a biologically active fragment, derivative or analog thereof.
