BURGER, MATTHEW T.,柏格 马修T,柏格 馬修T,HAN, WOOSEOK,韩宇锡,韓宇錫,LAN, JIONG,兰炯,蘭炯,NISHIGUCHI, GISELE,尼希古奇 吉塞尔,尼希古奇 吉塞爾
申请号：
TW098129413
公开号：
TWI434843B
申请日:
2009.09.01
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
New compounds, compositions and methods of inhibition of Provirus Integration of Maloney Kinase (PIM kinase) activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one PIM kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase- mediated disorder, such as cancer.本發明係提供在人類或動物病患中抑制與腫瘤發生有關聯之馬洛尼(Maloney)前病毒整合激酶(PIM激酶)活性之新穎化合物、組合物及方法。在某些具體實施例中,該化合物與組合物係有效抑制至少一種PIM激酶之活性。該新穎化合物與組合物可單獨使用,或併用至少一種關於治療絲胺酸/蘇胺酸激酶或受體酪胺酸激酶所媒介病症(譬如癌症)之其他藥劑。(無元件符號說明)
