Hallen-Adams Heather E.,Scott-Craig John S.,Walton Jonathan D.,Luo Hong
申请号:
US201715437359
公开号:
US9932571(B2)
申请日:
2017.02.20
申请国别(地区):
美国
年份:
2018
代理人:
Schwegman Lundberg & Woessner, P.A.
摘要:
The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptides and cyclic peptide production in mushrooms. In particular, the present invention relates to using genes and proteins from Galerina species encoding peptides specifically relating to amatoxins in addition to proteins involved with processing cyclic peptide toxins. In a preferred embodiment, the present invention also relates to methods for making small peptides and small cyclic peptides including peptides similar to amanitin. Further, the present inventions relate to providing kits for making small peptides.