Floris Louis Van Delft,Remon Van Geel,Maria Antonia Wijdeven
申请号：
US14807503
公开号：
US09504758B2
申请日:
2015.07.23
申请国别(地区):
US
年份:
2016
代理人:
摘要：
An antibody comprising a GlcNAc—S(A)x substituent is disclosed, wherein S(A)x is a sugar derivative comprising x functional groups A wherein A is independently selected from the group consisting of an azido group, a keto group and an alkynyl group and x is 1, 2, 3 or 4, wherein said GlcNAc—S(A)x substituent is bonded to the antibody via C1 of the N-acetylglucosamine of said GlcNAc—S(A)x substituent, and wherein said N-acetylglucosamine is optionally fucosylated. Also disclosed is an antibody-conjugate, in particular to an antibody-conjugate according to the Formula (20) or (20b), wherein AB is an antibody, S is a sugar or a sugar derivative, D is a molecule of interest, and wherein said N-acetylglucosamine is optionally fucosylated (b is 0 or 1).Also disclosed is a process for the preparation of a modified antibody, to a process for the preparation of an antibody-conjugate, and to said antibody-conjugate for use as a medicament.
