INJECTABLE SOLUTION AT PH 7, COMPRISING AT LEAST ONE BASAL INSULIN WHOSE PI IS BETWEEN 5.8 AND 8.5, A PRANDIAL INSULIN AND/OR A GASTROINTESTINAL HORMONE, AND A COPOLYAMINO ACID BEARING CARBOXYLATE CHARGES AND HYDROPHOBIC RADICALS
The invention relates to stable compositions physically in the form of an injectable aqueous solution whose pH is between 6.0 and 8.0, comprising at least: a) a basal insulin whose isoelectric point (pI) is between 5.8 and 8.5, b) a prandial insulin or a gastrointestinal hormone, and c) a copolyamino acid bearing carboxylate charges and at least one hydrophobic radical.L'invention concerne des compositions stables physiquement sous forme d'une solution aqueuse injectable, dont le pH est compris entre 6,0 et 8,0, comprenant au moins : a) une insuline basale dont le point isoélectrique (pi) est compris entre 5,8 et 8,5, b) une insuline prandiale ou une hormone gastrointestinale, et c) un co-polyaminoacide porteur de charges carboxylates et d'au moins un radical hydrophobe.
