Targeted Factor VIII molecules comprising a Factor VIII linked with at least one domain that specifically binds to a membrane protein on a red blood cell is provided. The disclosed targeted coagulation factors prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.本發明提供標靶因子VIII分子,其包含與至少一個特異地結合至紅血球上之膜蛋白的結構域連結的因子VIII。所揭示的標靶凝血因子延長其作用持續時間,並因而增進治療血液疾病,諸如A型血友病。