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isolated antibodies or binding antigen fragments thereof that may specifically bind to a dr6 polypeptide, in vitro methods of promoting survival of a nervous system cell, uses of a dr6 antagonist and in vitro methods of inhibiting dr6 binding with p75
专利权人:
BIOGEN IDEC MA INC
发明人:
KENNETH J. RHODES,R. BLAKE PEPINSKY,SHA MI
申请号:
BRPI0921837
公开号:
BRPI0921837A2
申请日:
2009.11.24
申请国别(地区):
BR
年份:
2016
代理人:
摘要:
The present invention relates to Death Receptor-6 (DR6) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to be important for regulating apoptosis in cells of the nervous system. In addition, it has been discovered that p75 is a ligand for DR6. As a result, this invention relates to methods for inhibiting the interaction of DR6 and p75 using DR6 and/or p75 antagonists. In addition, the methods described herein include methods of promoting survival of cells of the nervous system using DR6 antagonists, optionally in combination with p75 antagonists, and methods of treating neurodegenerative conditions by the administration of a DR6 antagonists, optionally in combination with a p75 antagonist.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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