Item-management systems, apparatus, and methods are described, preferably for management of items such as medicaments. In embodiments, an item-management system comprises a portable medicament container including plural cells, a docking station to which the container is temporarily docked, a sensor guide which may overlie the container when docked, visible information sources providing visible information to indicate cell into which each medicament is to be hand-loaded, and at least one controller operable to control the visible information. The sensor guide provides for medicament or item detection and for positive feedback confirming that the medicament or other item has been loaded into the correct cell.