Aleksandr V. YURKOVETSKIY,Mao YIN,Timothy B. LOWINGER,Joshua D. THOMAS,Cheri A. STEVENSON,Venu Reddy GURIJALA
申请号：
US15814914
公开号：
US20180140716A1
申请日:
2017.11.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.
