XUE, SONG,KARNATI, VISHNU VARDHAN REDDY,LIVINGSTON, ROBERT C.,BARDEN, TIMOTHY CLAUDE,SCHAIRER, WAYNE C.
申请号：
CA3029376
公开号：
CA3029376A1
申请日:
2017.07.06
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present disclosure relates to novel processes for the preparation of compounds useful as stimulators of soluble guanylate cyclase (sGC). These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula (I), including Compound ( I), Compound (IA) and Compound (IB), in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.
