Xanthine derivatives have anti-inflammatory, anti-pain hypersensitivity and control of peripheral and cerebral neuropathic pain properties through inhibition of MAPK and NF-κB activation. Therefore, Xanthine derivatives might be a potential agent for the control of peripheral and cerebral neuropathic pain.茶鹼類衍生物可藉由抑制中樞與周邊神經壓迫損傷活化之MAPK以及NF-κB訊息傳遞路徑,進而具呈現抗發炎、改善痛覺過敏以及改善中樞與周邊神經性疼痛的特性。