Maria Amann,Peter Bruenker,Christina Claus,Claudia Ferrara Koller,Sandra Grau-Richards,Christian Klein,Viktor Levitski,Ekkehard Moessner,Joerg Thomas Regula,Pablo Umana
申请号：
US16522412
公开号：
US20190382507A1
申请日:
2019.07.25
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.
