THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;NOVOME BIOTECHNOLOGIES, INC.
发明人:
SONNENBURG, JUSTIN L.,WHITAKER, WESTON R.,STANLEY, ELIZABETH,DELOACHE, WILLIAM C.
申请号：
CA3048669
公开号：
CA3048669A1
申请日:
2017.12.14
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Compositions and methods are provided for modulating growth of a genetically modified bacterial cell present in a human organ, for modulating growth of a genetically modified bacterial cell in an organ (e.g., gut), for displacing at least a portion of a population of bacterial cells in an organ, and for facilitating gut colonization by a genetically modified bacterial cell. Also provided are genetically modified bacterial cells, e.g., cells that include a heterologous carbohydrate-utilization gene or gene set that provides for the ability to utilize as a carbon source a rare carbohydrate of interest that is utilized as a carbon source by less than 50% of bacterial cells present in a human microbiome.
