A toothbrush sterilization cabinet includes a housing, a sliding plate movable in and out of the housing, a rack rotatably mounted at the sliding plate for holding toothbrushes and/or razors, a control circuit, a hot air generator consisting of an electrical heating element and an electrical fan, an UV germicidal lamp and an ozone generator for generating hot air, UV light or ozone, and a tact switch for driving the control circuit to turn on the hot air generator, the UV germicidal lamp and/or the ozone generator for a predetermined length of time.