Jason Allan Wiles,Qiuping Wang,Venkat Rao Gadhachanda,Godwin Pais,Akihiro Hashimoto,Dawei Chen,Xiangzhu Wang,Atul Agarwal,Milind Deshpande,Avinash S. Phadke
申请号：
US14631233
公开号：
US09695205B2
申请日:
2015.02.25
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof, wherein R12 or R13 on the A group is an amide substituent (R32) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.
