One embodiment of the present invention comprises a multi-functional patient transfer device for transferring mobility-impaired patients. In one embodiment, the multi-functional patient transfer device includes a lift cart and one or more lift components. The lift components may attach to the lift cart and/or other lift components. The lift components may include frontal bars, a tabletop, a central arm, lifting forks, a hoist, a knee blocker, footrests, a transfer chair, detachable handles, and/or safety cushions. Embodiments of the present invention may include one or more patient interfaces. The patient interfaces may attach to the lift cart and/or one or more lifting components. The patient interfaces may include slings, chairs, straps, harnesses, and/or transfer sheets. In one embodiment, the patient interfaces may include foldable panels. In one embodiment, the patient interfaces may include a buttock/link support. Example embodiments of methods of the present invention may include frontal transfers, lateral seated transfers, lateral bed transfers, and sit-to-stand transitions.