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Preparation from Tenebrio molitor larvae with antioxidant activity, process for its preparation and pharmaceutical product on its base
专利权人:
CIUHRII Veaceslav
发明人:
CIUHRII Veaceslav,ЧУХРИЙ Вячеслав
申请号:
MD20120131
公开号:
MD4296C1
申请日:
2012.12.28
申请国别(地区):
MD
年份:
2015
代理人:
摘要:
The invention relates to the pharmaceutical field, namely to a preparation from Tenebrio molitor larvae with antioxidant activity, a process for its preparation and a pharmaceutical product on its base.The preparation derived from the biomass of Tenebrio molitor larvae, according to the invention, comprises: lyophilized hydroalcoholic extract - 45…80% and vaseline oil - the rest, and manifests activity of inhibiting the peroxidation of lipoproteins IC50% of16 mg/ml and the nitroxide radical IC50% of20 mg/ml.The process for producing the preparation, according to the invention, consists in that Tenebrio molitor larvae are grown on an artificial nutrient medium, then are collected the last age larvae, are washed, disinfected with ultraviolet rays, frozen-thawed and homogenized. From the homogenized biomass is carried out the aqueous extraction for 60…90 min, followed by 70% ethanol extraction, the extracts are concentrated by vacuum evaporation, are combined, lyophilized and mixed with vaseline oil.The pharmaceutical product with antioxidant activity in the form of rectal suppositories comprises, per one suppository with the mass of 2 g: preparation derived from Tenebrio molitor larvae in vaseline oil - 0.25 g and semisynthetic glycerides - 1.75 gInvenţia se referă la domeniul farmaceutic, şi anume la un preparat din larve de Tenebrio molitor cu acţiune antioxidantă, la un procedeu de obţinere a acestuia şi la un produs farmaceutic pe baza lui.Preparatul obţinut din biomasa larvelor de Tenebrio molitor, conform invenţiei, conţine: extract hidroalcoolic liofilizat - 45…80% şi ulei de vaselină - restul, şi manifestă activitate de inhibiţie a peroxidării lipoproteinelor CI50% de 16 mg/ml şi a radicalului oxidului nitric CI50% de 20 mg/ml.Procedeul de obţinere a preparatului, conform invenţiei, constă în aceea că se cresc larvele de Tenebrio molitor pe un mediu nutritiv artificial, apoi se colectează larvele de ultima vârstă, se spală, se dezinfectează cu raze UV, se cong
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