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Diarylether derivatives as antitumor agents
专利权人:
Takashi Nakagawa;Hideki Takasu;Masaaki Motoyama;Satoshi Yamada;Kumi Higuchi;Shun Otsuji;Yutaka Kojima;Keisuke Miyajima;K;Hironori Matsuyama;Takeshi Kodama;Koichi Yasumura;Kenji Ohnishi;Makoto Sakamoto
发明人:
Hironori Matsuyama,Kenji Ohnishi,Takashi Nakagawa,Hideki Takasu,Makoto Sakamoto,Kumi Higuchi,Keisuke Miyajima,Satoshi Yamada,Masaaki Motoyama,Yutaka Kojima,Koichi Yasumura,Takeshi Kodama,Shun Otsuji,K
申请号:
US12095930
公开号:
US08236826B2
申请日:
2006.12.04
申请国别(地区):
US
年份:
2012
代理人:
摘要:
An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.
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