WARREN, GARY,VUCICA, YVONNE,KEMPF, CHRISTOPH,STUCKI, MARTIN
申请号：
CA2920391
公开号：
CA2920391A1
申请日:
2014.08.08
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
A method for purifying Apo A-l is provided including the steps of providing a solution comprising Apo A-l and guanidine hydrochloride and filtering the solution through a filter having a pore size in a range from 15 nrn to 35 nm to thereby reduce viral contamination of the Apo A-l. An Apo A-f preparation is provided having at least a 12 log LRV (log reduction value) for a parvovirus and/or at least 9 log LRV for a non-enveloped virus and/or at least 8.5 log LRV for a lipid enveloped virus. Also provided are pharmaceutical compositions and reconstituted high density lipoprotein formulation comprising Apo A-l and methods of treating diseases disorders or conditions.
