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COMPLEXE PROTEINIQUE POLYVALENT
专利权人:
IBC PHARMACEUTICALS;IMMUNOMEDICS, INC.
发明人:
申请号:
EP04750590.4
公开号:
EP1618181B1
申请日:
2004.04.22
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The invention provides for a polyvalent protein complex (PPC) comprising two polypeptide chains generally arranged laterally to one another. Each polypeptide chain typically comprises 3 or 4 "v-regions", which comprise amino acid sequences capable of forming an antigen binding site when matched with a corresponding v-region on the opposite polypeptide chain. Up to about 6 "v-regions" can be used on each polypeptide chain. The v-regions of each polypeptide chain are connected linearly to one another and may be connected by interspersed linking regions. When arranged in the form of the PPC, the v-regions on each polypeptide chain form individual antigen binding sites.
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