Ltd. Xinchang Pharmaceutical Factory;Zhejiang Medicine Co.
发明人:
Xinde Xu,Di Zhou,Lihua Zhang,Bin Shao
申请号：
US15767772
公开号：
US20180303761A1
申请日:
2015.10.12
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides a method of preparing highly stable microcapsule powders or microparticles containing a fat-soluble nutrient having multiple double bonds. The method includes a) dissolving the fat-soluble nutrient having multiple unsaturated double bonds to prepare an oil phase； b) dissolving a part of a capsule shell material into water to prepare an aqueous phase； c) shearing the aqueous phase and the oil phase, and mixing and emulsifying the same to obtain an emulsion； d) homogenizing the emulsion by a standard high-pressure homogenizer, to make the emulsion obtain droplets in the emulsion with an average particle diameter at a nanometer level, thereby producing a nanometer scale emulsion； e) directly adding a remaining part of the capsule shell material into the homogenized nanometer scale emulsion, and shearing, mixing, and dissolving the same to obtain a twice-embedded emulsion； and f) performing spray granulation on the twice-embedded emulsion, and drying resultant granules to obtain the highly stable microcapsule powder or microparticles.
