MACDONALD, Lynn,TU, Naxin,GURER, Cagan,STEVENS, Sean,MURPHY, Andrew, J.
申请号：
DK10791039
公开号：
DK2516457T3
申请日:
2010.12.17
申请国别(地区):
DK
年份:
2018
代理人:
摘要：
Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity Fc³R locus, and wherein the mouse is capable of expressing a functional FcR³-chain. Genetically modified mice are described, including mice that express low affinity human Fc³R genes from the endogenous Fc³R locus, and wherein the mice comprise a functional FcR³-chain. Genetically modified mice that express up to five low affinity human Fc³R genes on accessory cells of the host immune system are provided.
