Donald J. Kellerman,Shashidhar H. Kori,Scott W. Borland,Thomas A. Armer
申请号：
US14699797
公开号：
US20150238412A1
申请日:
2015.04.29
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed are compositions of matter and related methods that provide a metered dose inhaler that includes a formulation having a dose that comprises a hydrofluoroalkane propellant and dihydroergotamine mesylate particles wherein the dose includes between 0.1 mg to 4 mg of dihydroergotamine mesylate wherein the dihydroergotamine mesylate particles have a cumulative drug substance particle size distribution with d10>0.5 micron volumetric median diameter and d90<5.0 micron volumetric median diameter.
