The invention relates to a compound of general formula ().R1 is hydrogen, halogen, lower alkyl, lower alkoxy, halogen or cyano substituted lower alkoxy；R2 is halogen substituted hydrogen, lower alkyl or lower alkyl；R3 stands for phenyl, benzo [, 1,3] [, 2,3-dihydro-benzofuran-5-yl or 5-6 chain heteroaryl, phenyl and 5-6 chain heteroaryl, which can be selected from cyano, nitro, amino and dialkyl groups less than - amino, alkyl group less than - sulfo, alkoxy group less than, alkoxy group Low halogen substituted alkoxy, low halogen, low alkyl, low halogen substituted alkyl or low hydroxy substituted alkyl；X is lower alkyl,-CH2--ch2ch2- or -ch (lower alkyl) ch2-；R is the lower hydrogen or alkyl；N is 1 or 2；Or pharmaceutically acceptable acid addition salts, corresponding racemic mixtures or corresponding enantiomers and / or optical isomers thereof. The compound can be used for the treatment of schizophrenia, obsessive-compulsive personality disorder, depression, bipolar disease, anxiety disorder.Normal aging, epilepsy, retinal degeneration, brain injury, spinal cord injury, post-traumatic stress disorder, panic disorder, Parkinson's disease, dementia, Alzheimer's disease, mild cognitive impairment, cognitive impairment caused by chemotherapy Down's syndrome, autism ghost disorder, hearing loss, tinnitus disorder, poliomyelitis, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, cerebrovascular disease, radiotherapy, chronic stress, neuroactive substance abuseFor example, alcohol, opiates, methamphetamine, phencyclidine and cocaine.La présente invention concerne des composés de formule générale (i), dans laquelle r1 représente hydrogène, halogène, alkyle inférieur, alcoxy inférieur, alcoxy inférieur substitué par halogène ou cyano ； r2 représente hydrogène, alkyle inférieur ou alkyle inférieur substitué par halogène ； r3 représente phényle, benzo[1,3]dioxolyle, 2,3-dihydro-benzofuran-5-yle ou un hétéroaryle à 5 et 6 chaînons, phényle et les gro
