The Trustees of the University of Pennsylvania;Inovio Pharmaceuticals, Inc.
发明人:
David B. Weiner,Jian Yan,Bernadette Ferraro,Niranjan Y. Sardesai,Mathura P. Ramanathan
申请号：
US14552030
公开号：
US09399056B2
申请日:
2014.11.24
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.
