ELIS WINFRIED,ETTENBERG SETH,GARNER ANDREW PAUL,HAUBST NICOLE,KUNZ CHRISTIAN CARSTEN SILVESTER,REISINGER SPRAGUE ELIZABETH ANNE
申请号：
NZ60733711
公开号：
NZ607337A
申请日:
2011.08.22
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is an isolated antibody or fragment thereof that recognizes a conformational epitope of a HER3 receptor, wherein the conformational epitope comprises amino acid residues within domain 2 and domain 4 of the HER3 receptor, and wherein the antibody or fragment thereof blocks both ligand-dependent and ligand-independent signal transduction. Also disclosed is the use of the above-described antibody or fragment thereof for the manufacture of a medicament for the treatment of a cancer mediated by a HER3 ligand-dependent signal transduction or ligand-independent signal transduction pathway selected from the group consisting of breast cancer, colorectal cancer, lung cancer, multiple myeloma, ovarian cancer, liver cancer, gastric cancer, pancreatic cancer, prostate cancer, acute myeloid leukaemia, chronic myeloid leukaemia, osteosarcoma, squamous cell carcinoma, peripheral nerve sheath tumours, schwannoma, head and neck cancer, bladder cancer, oesophageal cancer, glioblastoma, clear cell sarcoma of soft tissue, malignant mesothelioma, neurofibromatosis, renal cancer, and melanoma.
