PROBLEM TO BE SOLVED: To provide means for activating Tie2 conveniently to improve a blood flow and improves a lymph flow, and also improves various symptoms of the body.SOLUTION: According to the present invention, there is provided a Tie2 activating composition comprising a persimmon leaf extract.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】簡便にTie2を活性化する手段を提供すること、及び、血流改善やリンパ流を改善し、ひいては体の諸症状を改善すること。【解決手段】柿葉抽出物を含む、Tie2活性用組成物。【選択図】なし