Disclosed is a unit dosage form comprising a thin water-soluble film matrix, wherein (a) said film matrix comprises at least one water-soluble matrix polymer (b) said film matrix comprises 10-200 micrograms of estradiol, or a therapeutically equivalent amount of a hydrate of estradiol or a therapeutically equivalent amount of a pharmaceutically acceptable ester of estradiol and (c) said film matrix has a thickness of less than 300 micrometres, wherein the estradiol, hydrate of estradiol, or ester of estradiol is present in the unit dosage form in non-complexed form. Said dosage form is suitable for treating a physical condition selected from the group consisting of osteoporosis, headaches, nausea, depression, vasomotor symptoms (such as hot flushes, sweating attacks including night sweats, and palpitations), symptoms of urogenital atrophy, decrease in bone mineral density, and increased risk or incidence of bone fracture
