The present invention relates to a bifunctional angiogenesis inhibitor having VEGF inhibitory activities and FGF inhibitory activities and capable of inhibiting VEGF and FGF dual factors or high sugar-induced cell proliferation, cell migration and/or lumen formation. The present invention also relates to use of the bifunctional vascular inhibitor for inhibiting retinal angiogenesis, such as diabetic retinopathy, age-related macular degeneration.