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COMPOSITIONS AND METHODS FOR TREATMENT OF EAR DISORDERS
专利权人:
Evgenia Alpert
发明人:
Evgenia Alpert,Igor Spivak,Amir Bar-Ilan
申请号:
US13867837
公开号:
US20140066493A1
申请日:
2013.04.22
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject.
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