THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
ENGLEMAN, EDGAR G.,HSU, FRANK,BENIKE, CLAUDIA,LEVY, RONALD
申请号：
DK95923042
公开号：
DK0765386T3
申请日:
1995.06.13
申请国别(地区):
DK
年份:
2015
代理人:
摘要：
The present invention relates to methods of using isolated human dendritic cells to present exogenous antigens for the induction of immune responses in vivo. In particular, it relates to the isolation of dendritic cells from human blood, exposing the cells to lymphoma-derived immunoglobulins as antigens, and re-infusing the autologous antigen-pulsed dendritic cells into lymphoma patients to induce and/or augment a tumor-reactive immune response. The methods of the invention described herein have a wide range of applications, including but not limited to, the clinical use of antigen-pulsed dendritic cells as vaccines and/or immunotherapeutics against cancer and infectious agents such as viruses.
