CALEB HYUNG MIN PARK,JONG SOO WOO,JAE HYUN PARK,YONG IL KIM,JIN CHEUL KIM,MYEONG KI JUNG
申请号：
ARP160101985
公开号：
AR105203A1
申请日:
2016.06.30
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
A Solid oral formulation, as active principle, including irinotecan or one of its pharmaceutically acceptable salts, and an acidifying Agent. Claim 1: a Solid oral formulation that includes: irinotecan or one of its pharmaceutically acceptable salts； and an acidifying Agent.Claim 4: Solid oral formulation of claim 2, in which the acidifying Agent selected from the group consisting of acetic acid, Citric Acid, lactic acid, and any combination of them. Claim 6: Solid oral formulation of claim 1, in which the amount of acidifying Agent is approximately 0.Approximately 2 parts to 10 parts by weight based on 1 part by weight of irinotecan or one of its pharmaceutically acceptable Salts. Claim 7: oral Solid formulation of claim 1, in which the solid oral formulation is in the form of Granules, Capsule, or tablet.Claim: The 9 Solid oral formulation of claim 8, in which the solid oral formulation comprises approximately 20% by weight to about 80% by weight of the diluent, about 1% by weight to about 10% by weight of the Binder, of approximately 2% in Weight approximately 7% by weight of the disintegrant, or about 0.5% by weight to about 5% by weight of the LUBRICANT based on a total weight of Solid oral formulation.The Method of claim 14: claim 13, in which the wet granulation comprises Forming Granules by granulating a mixture of irinotecan or one of its pharmaceutically acceptable Salts and the Solvent together with a Binder solution that includes a Binder, in the The acidifying Agent is added to the mixture and / or the Binder Solution.Una formulación oral sólida que, como principio activo, incluye irinotecán o una de sus sales farmacéuticamente aceptables, y un agente acidificante. Reivindicación 1: Una formulación oral sólida qua comprende: irinotecán o una de sus sales farmacéuticamente aceptables； y un agente acidificante. Reivindicación 4: La formulación oral sólida de la reivindicación 2, en la que el agente acidificante se selecciona del grupo que consiste en áci
