Jun LIANG,Rohan V. MENDONCA,Michael SIU,John TELLIS,Weiru WANG,BinQing WEI,Bryan CHAN,Edna F. CHOO,Joy DROBNICK,Lewis J. GAZZARD,Timothy HEFFRON
申请号：
US16592502
公开号：
US20200108075A1
申请日:
2019.10.03
申请国别(地区):
US
年份:
2020
代理人:
摘要：
3-Carbonylamino-8-aminoisoquinoline compounds of formula (I):variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the 3-carbonylamino-8-aminoisoquinoline compounds.
