Celeste Aida S. Regino,William J. McBride,Chien-Hsing Chang,David M. Goldenberg
申请号：
US14564243
公开号：
US20150086482A1
申请日:
2014.12.09
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present application discloses compositions and methods of use of peptide targetable constructs for detection, diagnosis and/or imaging of cancer. In preferred embodiments, the targetable construct comprises at least one hapten, at least one fluorescent probe, a chelating moiety and a group IIIA metal-18F complex attached to the chelating moiety. For in vivo use, the labeled targetable construct is used in conjunction with a bispecific antibody comprising at least one binding site for the hapten and at least one binding site for a tumor-associated antigen. Cancers may be detected, diagnosed and/or imaged by fluorescence spectroscopy and/or PET or SPECT. Preferably, imaging is performed in intraoperative, intraperitoneal, laparoscopic, endoscopic or intravascular procedures.
