Pharmaceutical compositions and their methods of use

• 收藏
• 分享

专利权人:

AbbVie Inc.

发明人:

Gopalakrishnan, Murali,Honore, Marie P.,Lee, Chih-hung,Malysz, John,Ji, Jianguo,Li, Tao,Schrimpf , Michael R.,Sippy, Kevin B.,Anderson, David J.

申请号：

ES10163998

公开号：

ES2558054T3

申请日:

2007.12.12

申请国别(地区):

ES

年份:

2016

代理人:

摘要：

A composition, comprising: (i) a nicotinic acetylcholine receptor ligand, wherein the nicotinic acetylcholine receptor ligand alters the activity of the receptor, and wherein the nicotinic acetylcholine receptor ligand is a 3- heterocyclic ether compound pyridoxylalkyl； and (ii) a positive allosteric modulator of the α4β2 subtype acetylcholine nicotinic receptor mixed with at least one pharmaceutically acceptable excipient, wherein the modulator enhances the activity of the receptor, wherein the nicotinic α4β2 subtype positive allosteric modulator is selected from the group that consists of: 3,5-diphenylisoxazole； 3- (3- (pyridin-3-yl) -1,2,4-oxadiazol-5-yl) benzonitrile； 3,5-di (pyridin-3-yl) -1,2,4-oxadiazole； 3- (5- (pyridin-3-yl) -1,2,4-oxadiazol-3-yl) benzonitrile； 3- (5- (6-fluoropyridin-3-yl) -1,2,4-oxadiazol-3-yl) benzonitrile； 5- (5-bromopyridin-3-yl) -3- (pyridin-3-yl) -1,2,4-oxadiazole； 3- (pyridin-3-yl) -5- (3- (trifluoromethylsulfonyl) phenyl) -1,2,4-oxadiazole； 3- (3- (6-methylpyridin-3-yl) -1,2,4-oxadiazol-5-yl) benzonitrile； 5- (5- (pyrrol-1-yl) pyridin-3-yl) -3- (pyridin-3-yl) -1,2,4-oxadiazole； 5- (3- (pyridin-3-yl) -1,2,4-oxadiazol-5-yl) pyridin-3-ol； 5- (3,4-difluorophenyl) -3- (pyridin-3-yl) -1,2,4-oxadiazole； 5- (2,3-difluorophenyl) -3- (pyridin-3-yl) -1,2,4-oxadiazole； 5- (pyrazin-2-yl) -3- (pyridin-3-yl) -1,2,4-oxadiazole； 5- (3,5-difluorophenyl) -3- (pyridin-3-yl) -1,2,4-oxadiazole； 5- (2,3,5-trifluorophenyl) -3- (pyridin-3-yl) -1,2,4-oxadiazole； 5- (2,4,5-trifluorophenyl) -3- (pyridin-3-yl) -1,2,4-oxadiazole； 5- (2,5-difluorophenyl) -3- (pyridin-3-yl) -1,2,4-oxadiazole； 5- (4-Chloro-2,5-difluorophenyl) -3- (pyridin-3-yl) -1,2,4-oxadiazole； 5- (5-methylpyrazin-2-yl) -3- (pyridin-3-yl) -1,2,4-oxadiazole； 4- (3- (pyridin-3-yl) -1,2,4-oxadiazol-5-yl) benzonitrile； 2,3, G-trifluoro-5- (3- (pyridin-3-yl) -1,2,4-oxadiazol-5-yl) phenol； 2-fluoro-5- (3- (pyridin-3-yl) -1,2,4-oxadiazol-5-yl) phenol； 2-fluoro-4- (3- (pyridin-3-yl) -1,2,4-oxadiazol-5-y

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/