HUMANIZED ANTIBODIES TRANSMIGRATING THE BLOOD-BRAIN BARRIER AND USES THEREOF

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专利权人:

National Research Council of Canada

发明人:

Danica Stanimirovic,Kristin Kemmerich,Yves Durocher,Traian Sulea

申请号：

US16314891

公开号：

US20190241653A1

申请日:

2017.07.04

申请国别(地区):

US

年份:

2019

代理人:

摘要：

The present invention relates to antibodies and fragments thereof derived by humanization of an existing antibody, and methods of making them. The humanized antibodies of the present invention show enhanced binding to the brain endothelial antigen, improved transmigration across the blood-brain barrier, and increased thermal stability relative to the parent non-humanized antibody.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/