Provided are compositions and methods for use in prophylaxis of puerperal metritis and improving reproductive function of ruminants. The methods and compositions are for subcutaneous administration and are provided as veterinary compositions and as articles of manufacture. The veterinary composition comprises three proteins of F. necrophorum leukotoxin (LKT), E. coli type 1 fimbrial adhesin (FimH), and T. pyogenes pyolysin (PLO), and can further comprise inactivated whole cells of Escherichia coli (E. coli), Trueperella pyogenes (T. pyogenes) and Fusobacterium necrophorum (F. necrophorum).
