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ISOTOPE LABELED 2-ARYLPROPIONIC ACID COMPOUNDS AND PROCESS FOR PRODUCTION OF SAME, AND MOLECULAR PROBE FOR POSITRON EMISSION TOMOGRAPHY AND METHOD FOR IMAGING OF CYCLOOXYGENASE AND THE LIKE USING SAME
专利权人:
RIKEN
发明人:
TAKASHIMA, MISATO,SHUKURI, MIHO,GOTO, MIKI,DOI, HISASHI,ONOE, HIROTAKA,SUZUKI, MASAAKI,WATANABE, YASUYOSHI
申请号:
EP10806375
公开号:
EP2463263A4
申请日:
2010.07.29
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
Disclosed are: labeled NSAIDs compounds which can be produced within a short time, can be used suitably for a PET method, and enable the imaging of cyclooxygenase-2 and a process for producing the labeled NSAIDs compounds. Specifically disclosed are isotope-labeled 2-arylpropionic acid compounds, each of which is a compound represented by general formula (1) (wherein Ar represents an aryl group which may have a substituent R1 represents any one selected from 11CH3, CH2 18F and CF2 18F and R2 represents a hydrogen atom, or an alkyl group which may have a branch, wherein a compound wherein Ar is a benzene ring, R1 is 11CH3, and R2 is a hydrogen atom is excluded), or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof.
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