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TEKUĆI FARMACEUTSKI PRIPRAVAK KOJI SADRŽI PEMETREKSED
专利权人:
Synthon B.V.
发明人:
Zaludek, Borek
申请号:
HRP20200387
公开号:
HRP20200387T1
申请日:
2020.03.09
申请国别(地区):
HR
年份:
2020
代理人:
摘要:
The present invention relates to a liquid pharmaceutical composition suitable for parenteral administration comprising: a) pemetrexed diacid; b) at least one organic amine; c) at least one antioxidant; d) 10-200 mg/ml of propylene glycol; and e) one or more parenteral solvents, wherein the preparation thereof is conducted in an atmosphere of inert gas and wherein the organic amine(s) is present in an amount sufficient to reach a pH of the composition in the range from 8.3 to 9.1 The invention further relates to the use of said liquid pharmaceutical composition as medicament in the treatment of malignant pleural mesothelioma and non-small cell lung cancer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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