THE U.S.A. AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; INC.;THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;THE BRIGHAM AND WOMENS HOSPITAL
The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia； diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism； or diseases, disorders, or syndromes caused by hyperlipidemia.
