Provided is a hyaluronic acid (HA) composition for use in treating or preventing mucosa related disorders or diseases including a mixture of HAs having different average molecular weights and different rheological isolation tissue scaffold and degradation properties. The resulting formulation demonstrates an optimal balance between adhesion tissue scaffold and treating time on the treatment and prevention of mucosa related disorders or diseases including conjunctivitis otitis allergic rhinitis gingivitis oral ulcer bronchitis gastroesophageal reflux disease (GERD) esophagitis gastritis enteritis peptic ulcer inflammatory bowel disease (IBD) irritable bowel syndrome (IBS) urethritis cystitis and vaginitis.
