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Process for manufacturing vaccines
专利权人:
Pierre Duvivier;Ralph Leon Biemans
发明人:
Ralph Leon Biemans,Pierre Duvivier
申请号:
US13457891
公开号:
US08846049B2
申请日:
2012.04.27
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present application discloses an improved method for conducting saccharide—protein conjugation reactions using carbodiimide condensation chemistry. Depending on the nature of the saccharide or protein carrier involved, the quality of the conjugate may be improved by adding one of the reaction components slowly to the reaction mixture. Immunogenic compositions are further provided comprising the saccharide-protein conjugates made by the methods disclosed.
来源网站:
中国工程科技知识中心
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