This Hair is bright be related to having Xia Shi structure compound: wherein Y, A, W, B, U, V, X and Ar1, which have, illustrates that Books Zhong Give goes out Han Righteousness, and the compound can be used as p38 and Elixirs is inhibited to be controlled in Treatment with what.本發明涉及具有下式結構的化合物:其中Y、A、W、B、U、V、X和Ar1具有說明書中給出的含義,所述化合物可作爲p38抑制劑用於治療中。