新穎雜芳基化合物及其作為藥物之用途农业专利-农业学术服务平台

发明人:: DAHMANN, GEORG,达曼　乔治,達曼　喬治,HOFFMANN, MATTHIAS,霍夫曼　玛莎思,霍夫曼　瑪莎思,KLICIC, JASNA,克里克　杰斯纳,克里克　傑斯納,LAMB, DAVID JAMES,兰伯　大卫　詹姆斯,蘭伯　大衛　詹姆斯,MCCARTHY, CLIVE,麦可卡西　克莱夫,麥可卡西　克萊夫,NAPIER, SPENCER,纳比尔　史宾塞,納比爾　史賓塞,PARR,达曼乔治,達曼喬治,霍夫曼玛莎思,霍夫曼瑪莎思,克里克杰斯纳,克里克傑斯納,兰伯大卫詹姆斯,蘭伯大衛詹姆斯,麦可卡西克莱夫,麥可卡西克萊夫,纳比尔史宾塞,納比爾史賓塞

摘要：: The invention relates to new substituted heteroaryls of formula 1wherein A is selected from the group consisting of N and CH D is selected from the group consisting of CH, E is selected from the group consisting of C end N, T is C, G is selected from the group consisting of C and N, and wherein each of the broken (dotted) double bonds in ring 1 are selected from either a single bond or a double bond under the proviso that all single and double bonds of ring 1 are arranged in such a way that they all form together with ring 2 an aromatic ring system, and wherein R1, M and R3 are defined according to claim 1, and to the above compounds for the treatment of a disease selected from the group consisting of asthma, COPD, allergic rhinitis, allergic dermatitis, lupus erythematodes, lupus nephritis and rheumatoid arthritis.本發明係關於新穎的經取代之式1雜芳基化合物，其中A係選自由N及CH組成之群，D係選自由CH組成之群，E係選自由C及N組成之群；T為C，G係選自由C及N組成之群；且其中環1中之虛線(點線)雙鍵各選自單鍵或雙鍵，其限制條件為環1中之所有單鍵及雙鍵的方式排列可以使得其皆與環2一起形成芳族環系，且其中R1、M及R3如技術方案1所定義；及上述化合物用於治療選自由以下組成之群的疾病：哮喘、COPD、過敏性鼻炎、過敏性皮炎、紅斑狼瘡、狼瘡腎炎及類風濕性關節炎。